Introduction Defect in coagulation present even in the early stage of acute pancreatitis. D-dimer is a small protein particle generated during blood clot disintegration due to lysis of fibrin. It is an accurate indicator of lysis of fibrin, so has an association with the severity of pancreatic inflammation. The study was undertaken to know the utility of d-dimer to forecast organ failure or complications in acute pancreatitis.
Methodology From June 2019 to Jan 2020, 50 patients of acute pancreatitis were enrolled in this prospective study. Patients were subjected to the d-dimer test within 24 hours after admission. The patients were split into two groups; with organ failure (complications) and without any complications. The result of the d-dimer test was correlated with these groups.
Results 50 patients of acute pancreatitis were included in this study. Organ failure or local complications observed included impairment renal in 4 patients (16%), vasopressor requirement in 4(8%), pulmonary dysfunction in 5 (10%) and multiple organ failure syndrome (MODS) in 5 (10%). The sensitivity of d-dimer was 75% and specificity was 90%. Positive predictive value and negative predictive value of ddimer were 91%, 74% respectively.
Conclusions D-dimer is an accurate and cost-effective test to predict organ failure or local complications in a patient of acute pancreatitis.