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Pathogenesis of neuropathic foot ulcers in diabetes: understanding current concepts

Authors:

Gayan Neomal Samarasinghe Ekanayake ,

National Hospital Sri Lanka, LK
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Suranga Ravinda Manilgama

North Colombo Teaching Hospital, LK
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Abstract

The diabetic foot ulcer can occur in one out of four diabetic
individuals during their lifetime [1]. Ischaemia, neuropathy,
or a combination are the primary risk factors for non-healing
foot ulcers. In the presence of these elements, even trivial
trauma can trigger ulceration [2]. Moreover, neuropathy is
associated with 85% of these ulcers [3] and ischaemia is
associated with 10-60% in different case series [4].
Neuropathic foot ulcers can occur in three ways; deformity
related trophic ulceration, trauma-Infection related non-
healing ulceration, superadded peripheral vascular disease-
related ulceration.

This account is on the classic pathway of microangiopathy
leading to peripheral neuropathy, deformity and ulceration.
This group of patients will present with callus leading to
ulceration. They represent 30% out of all types of diabetic
foot ulcers [4].

How to Cite: Ekanayake GNS, Manilgama SR. Pathogenesis of neuropathic foot ulcers in diabetes: understanding current concepts. Sri Lanka Journal of Surgery. 2021;39(3):60–4.
Published on 30 Nov 2021.
Peer Reviewed

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